When undergoing fertility treatment, many couples ask what more can be done to improve IVF success rates. One area gaining increasing attention is advanced sperm selection, particularly for those affected by male factor infertility or high sperm DNA fragmentation. You might want to consider using ZyMot sperm selection if you or your partner have had a SpermComet DNA Fragmentation test that shows a high level of DNA damage.
ZyMot sperm selection is an innovative IVF add-on that offers a more natural and gentle way to select the healthiest sperm for IVF and ICSI, helping to reduce sperm DNA damage and potentially improve treatment outcomes.
The relationship between SpermComet and ZyMot is that they are complementary technologies used in male fertility treatment to address sperm DNA damage.
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The SpermComet is a diagnostic test used to measure the level of DNA fragmentation (damage) in a sperm sample. It provides crucial information about a hidden cause of infertility that standard semen analyses miss.
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The ZyMot is a sperm selection device (or "chip") used during fertility treatment (like ICSI) to select the healthiest and most motile sperm with lower levels of DNA fragmentation.
A high result on the SpermComet test often indicates that the use of the ZyMot device during a subsequent fertility procedure may be beneficial. We explain why below.
|
Feature |
SpermComet (Test) |
ZyMot (Device) |
|
Function |
Measures the percentage of DNA damage in individual sperm. |
Selects the best quality, progressively motile sperm with reduced DNA damage for use in assisted reproduction. |
|
Method |
The lab procedure involves embedding sperm in gel and using electrophoresis to make fragmented DNA appear like a "comet tail". |
The microfluidic device uses natural sperm motility to mimic the female reproductive tract, allowing only the fittest sperm to swim through a membrane filter. |
|
When used |
A diagnostic test performed before treatment to help determine the best course of action (e.g., whether to use IVF or ICSI, or if a ZyMot add-on is needed). |
Used on the day of the fertility procedure (IUI, IVF, or ICSI) as an alternative to conventional preparation methods like centrifugation. |
|
Primary Benefit |
Provides a more accurate diagnosis of male factor infertility issues than a standard semen analysis. |
Avoids the potential DNA damage to sperm that can be caused by the high-speed spinning (centrifugation) used in traditional sperm preparation. |
What Is ZyMot Sperm Selection?
ZyMot is a microfluidic sperm selection device used during IVF and ICSI treatment. Unlike traditional sperm preparation methods that rely on centrifugation (spinning), ZyMot allows sperm to swim naturally through a microscopic membrane.
This process closely mimics natural conception and helps identify sperm with:
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High motility
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Normal morphology
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Lower DNA fragmentation
By avoiding harsh processing, ZyMot supports the selection of sperm with superior DNA integrity — a key factor in embryo development and implantation.
How Does ZyMot Work in IVF and ICSI?
During treatment:
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A semen sample is placed into the ZyMot microfluidic chip
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Motile sperm swim through a micro-pore membrane
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Only the strongest sperm successfully pass through
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These selected sperm are then used for IVF or ICSI
Because centrifugation is avoided, there is less oxidative stress on sperm, helping to reduce sperm DNA damage compared with conventional preparation techniques.
Why Is Sperm DNA Fragmentation Important?
Even when sperm count and movement appear normal, DNA damage within the sperm can still affect fertility outcomes. High sperm DNA fragmentation has been linked to:
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Lower fertilisation rates
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Poor embryo development
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Implantation failure
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Recurrent miscarriage
Specialist tests such as the SpermComet test can measure sperm DNA fragmentation. Where elevated levels are identified, ZyMot IVF or ZyMot ICSI may be recommended to help select sperm with better DNA quality.
Who Is ZyMot Suitable For?
ZyMot may be particularly beneficial for patients experiencing:
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Male factor infertility
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High sperm DNA fragmentation
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Poor embryo quality in previous IVF cycles
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Repeated implantation failure
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Unexplained IVF or ICSI failure
It is often considered by couples seeking IVF options for male infertility or looking for ways to improve embryo quality.
Benefits of ZyMot as an IVF Add-On
As one of the most widely used IVF add-ons in the UK, ZyMot offers several potential benefits:
✔ Reduces Sperm DNA Damage
Studies show ZyMot significantly lowers DNA fragmentation compared with traditional sperm preparation methods.
✔ May Improve IVF and ICSI Outcomes
By selecting sperm with healthier DNA, ZyMot may support higher fertilisation, implantation, and pregnancy rates.
✔ Supports Better Embryo Quality
Healthier sperm DNA gives embryos a stronger genetic foundation from the very start.
✔ Gentle, Natural Sperm Selection
Microfluidic technology replicates the natural sperm selection process without harsh laboratory stress.
✔ Efficient for Fertility Laboratories
ZyMot integrates seamlessly into IVF and ICSI workflows, offering flexibility for embryology teams.
Important Considerations
ZyMot is an optional fertility treatment add-on, not a replacement for standard sperm preparation. While many clinics report positive clinical experience, ongoing research continues to explore broader outcomes.
Your fertility consultant will discuss:
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Whether ZyMot sperm selection is appropriate for your situation
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How it fits alongside sperm DNA testing
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The potential benefits based on your fertility history
Is ZyMot the Right IVF Add-On for You?
If you have been diagnosed with male factor infertility, high sperm DNA fragmentation, or have experienced poor embryo development or implantation failure, ZyMot may offer additional support in your treatment journey.
Understanding your options is key — and the right sperm selection method can make a meaningful difference.
Speak to Our Fertility Specialists
Our experienced team is here at IVF Matters to help you explore advanced sperm selection, sperm DNA testing, and personalised IVF treatment plans.
📞 Contact IVF Matters to book a FREE Advisory Call and find out more!
🧪 Ask about the SpermComet test and ZyMot IVF
📅 Take the next step towards informed, evidence-based fertility care
Because the healthiest beginnings often start at the smallest level.
