Nicotine Replacement Therapy (NRT) & Fertility  |  Reproductive Science Research

Nicotine Replacement Therapy (NRT) & Fertility | Reproductive Science Research

Author: Dr Irfana Koita  |  Published: 23 September 2024


Nicotine gum can potentially have negative effects on fertility for both men and women, though the impacts are generally less severe compared to smoking cigarettes.

For women:

Nicotine exposure through gum may disrupt hormone regulation and affect ovulation[1][2]. - It could potentially reduce uterine receptivity, making implantation of an embryo more difficult[1][2]. - Nicotine may damage fallopian tubes by altering gene expression[4].

For men: 

Nicotine from gum can reduce sperm motility and fertilization capacity[3][4]. - It may lower sperm count and semen volume[3][4]. - Nicotine exposure is associated with DNA fragmentation in sperm, which can prevent successful fertilization[3][4].

NRT is still considered a safer alternative

While nicotine gum delivers lower doses of nicotine compared to cigarettes, it still introduces nicotine into the body. This can impact reproductive functions, albeit likely to a lesser degree than smoking.

However, nicotine gum is generally considered a safer alternative for those trying to quit smoking while attempting to conceive[1][2].

If fertility is a concern, it's best to consult a doctor about using nicotine replacement therapy. Ideally, completely quitting nicotine use would be most beneficial for optimizing fertility for both men and women[1][2][3]. 

Frequently Asked Questions About Nicotine and Fertility

1. Do Nicotine Pouches Affect Sperm Quality?

Research specifically examining nicotine pouches and human sperm quality is limited. Studies on smoking and other tobacco products have identified associations with poorer semen parameters, but these findings cannot be directly applied to every nicotine pouch product.

2. Does Nicotine Affect Female Fertility?

Smoking is associated with reduced fertility and may affect ovarian function. However, the specific effects of nicotine alone, including nicotine pouches and nicotine replacement products, are less well understood. The risks depend partly on the product and type of exposure.

3. Can You Use Nicotine Gum While Pregnant?

Nicotine replacement therapy may be recommended during pregnancy when it helps someone stop smoking, as it avoids exposure to the many harmful chemicals in cigarette smoke. Speak to your midwife, GP or healthcare professional about the most appropriate option for you.

4. Does Nicotine Affect IVF Success?

Smoking is associated with poorer outcomes in assisted reproductive treatment, including IVF. However, evidence about the specific effects of nicotine gum and other nicotine-only products on IVF success is limited. Discuss nicotine use and smoking cessation with your fertility specialist before treatment.

Sources

[1] Effects of Nicotine on Sperm Characteristics and Fertility Profile in ... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719292/ 

[2] An Overview of E-Cigarette Impact on Reproductive Health - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053939/ 

[3] Smoking, Pregnancy and Fertility - ASH https://ash.org.uk/resources/view/smoking-pregnancy-and-fertility 

[4] How Smoking Can Affect Fertility | NICORETTE® https://www.nicorette.co.uk/getting-ready-to-quit/smoking-and-fertility